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Enhanced TAU Outcome in TAU Randomized Controlled Trial Years in the study No of personal examinations Additional therapeutic activity Reduction of psychological symptoms Survival rate (%) at end of study Estimated survival rate within 8 years1 RCPP [19 ] 4.5 y. 5 (3 cardiologic, 2 psycho logical) 33 group sessions à 90 min. Type A behaviour: −9.8%; ES2 : 0.72; 95%CI 0.89–0.56 92.8% 87.2 Jones and West [20 ] 1 y. 3 0 depression not specified for TAU 92.8% 42.4%1 M-HEART [21 ] 1 y. 3 (1 cardiological, 3 psychological) 0 BDI depression: - 9.5%; ES2 : 0.1; 95%CI 0.26–0.07 94.6% 56.8%1 ENRICHD [22 ] 2.4 y. 5 (cardiolog.,psychological) Active partnership Health booklet BDI depression: −33%; ES2 : 0.69; 95%CI 0.85–0.53 86.2%. 54.3% CREATE [23 ] 0.25 y 2 (cardiolog.,psychological) 12 × 20 min clinical management BDI: − 40.3% HAMD:-48%; ES2 : 1.81; 95%CI 2.2–1.42 100% / ? SWICHD [24 ] 7.1 y. 1(cardiolog, psychological; 2x questionnaires by letter) 0 depressive symptoms: −16.1%; ES3 : 0.25; 95%CI 0.64–0.14 80.1% / 77.6% SUPRIM [25 ] 7.8 y. 5 (cardiological, psychological) 0 Depression not reported 85.2% / 84.8% SPIRR-CAD [26 ] 2 y. 5 (2x cardiologic, 5x psychological) 30 min information on risk factors HADS-D − 13.4%; ES4 :0.41 95%CI 0.65–0.18 remission on HADS-D 35.8% 96.8% / 87.2%
1 8 years survival rate was predicted using survival data of the individual study. Presented studies differ in timebetween 0,25 years and 7.8 years. Mortality is higher in the year after the event. So in studies with a one or two years follow up period the estimated value of 8 years survival may be higher. 2 mean and standard deviation at baseline and follow up (RCCP:4.5 y.;M-Heart:1 y.; ENRICHD (depressedparticipants only): 6 months; CREATE:3 months) 3 mean and standard deviation at baseline and follow up (1–2 years), published by Koertge J et al. J Intern Med2007;263:281–293 4 LOCF ANCOVA mean and standard deviation at baseline and follow up (24 months)
